The purpose of this study was to empirically examine promoting factors of career self-reliance of corporate employees. A questionnaire was administered on a website to 669 corporate employees working in multiple companies. A path model of career self-reliance was developed based on the previous explorative study of psychological processes of career self-reliance as well as other related previous studies. The model proposed four variables; career transition experience, learning from work experience, leader-member exchange (LMX) and team-member exchange (TMX); which promoted career self-reliance. Analyses based on a structural equation modeling indicated that career transition experience, LMX and TMX promoted learning from work experience, and then learning from work experience promoted career self-reliance of employees.