Perceived negative changes of organizational climate are commonly attributed to the stressful nature of the job. This study examines an occupation-specific model of the stress process in nurses in which perceived negative changes of specific organizational climate dimensions were hypothesized to distress indirectly through the mediating effects of specific occupational stressors. The model proposes three perceived negative changes of organizational climate, namely an increase in their working hours, dilution of their group-solidarity and workplace becoming more demanding (e.g. customers demand more service). The SEM analysis on the responses of 592 female nurses revealed that,1) excessive perceived negative changes of organizational climate was associated with higher nursing occupational stressors, qualitative work load,2) excessive perceived negative changes of organizational climate was associated with higher nursing occupational stressors, conflict with other nursing staffs,3) qualitative work load and conflict with other nursing staffs were associated with higher distress, confirming our hypotheses.